Product Overview
MK 677 Ibutamoren by Dragon Pharma is the subject of this listing. Ibutamoren, the compound behind the code MK-677, is an oral growth hormone secretagogue supplied as a 25 mg tablet in a pack of 100. It is often filed next to the SARMs, but it is not one of them: it does not touch the androgen receptor at all. What it does is imitate ghrelin at the receptor that controls growth hormone release, which is why the effects people talk about are sleep, appetite and recovery rather than androgen-driven muscle growth.
It also carries an unusual status for a catalogue item. Ibutamoren was developed as an investigational drug and never approved for human consumption, so long-term safety data does not exist, and it sits in the WADA S2 class as prohibited at all times. That combination makes the details on this page more important than the headline.
The trade code MK-677 and the generic name ibutamoren describe the same non-peptide molecule, also studied as MK-0677 and LUM-201. It is orally active, which separates it from the injectable growth hormone peptides: no vial, no reconstitution, no needles. Your order is a box of 100 tablets at 25 mg each from Dragon Pharma, the same strength that appears in the clinical literature and the same count listed on the product page.
Two numbers matter when you are deciding what you are buying. The elimination half-life measured in beagles is 4-6 hours, which sounds short, but insulin-like growth factor 1 stays elevated for up to 24 hours after a single oral dose in humans. That gap between clearance and effect is the reason the reference schedule is one tablet a day instead of repeated dosing. The pack also does not come with a clinical label, because there is no approved label to reproduce.
Mechanism of Action
Ibutamoren binds the ghrelin receptor in the pituitary and hypothalamus and asks the pituitary to release growth hormone through its own signalling, rather than supplying the hormone from outside. Because the release is pulsatile and follows the body's own pathways, the pattern is different from injected somatropin, and the downstream effect is a rise in IGF-1 produced by the liver. That rise is the measurable marker, and it is what monitoring protocols track.
Two secondary effects come from the same receptor. Ghrelin signalling drives hunger, so appetite climbs; and ghrelin activity influences sleep architecture, which is the origin of the bedtime dosing habit. In a small study of 14 participants, 25 mg taken before sleep increased the proportion of REM sleep, by roughly 20 percent in younger subjects and by about 50 percent in older ones. Cortisol rises are also documented in the sources, and that is a laboratory marker worth following rather than a symptom to ignore.
Dosage Protocol
One tablet daily before sleep is the pattern the literature supports, and 25 mg is the dose that was actually studied. Starting lower is a common way to see how the appetite and lethargy responses land before committing to the full strength.
| Starting dose | 10-15 mg a day, taken before sleep |
| Standard dose | 25 mg a day, the clinically studied figure |
| Upper range | 25 mg a day; data above this is limited |
| Block length | 8-12 weeks, extended to 12-16 in some practice |
| Timing | Once daily at bedtime, because of the sleep and appetite effects |
| Female use | Not confirmed for women in the sources |
If you feel foggy or unusually sleepy during the day, the usual fix in practice is to move the dose earlier rather than to raise it. Anyone monitoring the compound should track IGF-1 and cortisol rather than judging progress by how they feel, since both markers move before anything visible does.
Suggested Protocols
Because the mechanism is separate from the androgen receptor, ibutamoren is often combined with compounds that act elsewhere. None of the arrangements below have clinical support as combinations, and the peptide pairing in particular has no human data at all.
What to Expect
The honest expectation is a slow hormonal shift rather than a training drug effect. Clinical work reported increased lean body mass without a change in total fat mass, which is a modest result and not the same thing as visible muscle gain.
Sleep and appetite changes usually show up in the first days to weeks. Anything beyond that, including the muscle claims, should be treated as gradual and partly unproven.
Side Effects and Management
Most of what users report is tolerable and dose-related, but the absence of approved human use means the list is short and the long-term picture is simply unknown.
Anyone with a glucose-handling problem, or anyone taking medication that affects blood sugar, is in the wrong place for this compound.
Keep the pack in its original blister and carton at room temperature, out of sunlight and away from the humidity of a bathroom or kitchen. Tablets of this type are sensitive to damp more than to heat, and a sealed container in a dry cupboard is enough. Note the date the pack was opened, keep the lot number with it, and store it where children and pets cannot reach it.
Do not repackage the tablets loose into a pill organiser for weeks at a time, and do not keep them in a fridge unless the label says so. If a tablet has softened, cracked or changed colour, discard it rather than taking it.
Post-Cycle Therapy
Ibutamoren is not an androgen and does not shut the gonadal axis down the way a steroid does, so there is no classic SERM recovery protocol attached to it. What it does need is a monitoring plan, because the markers it moves are silent.
If a SARM was run alongside the ibutamoren, its own recovery steps still apply: a SERM such as Nolvadex or Clomid belongs to the suppressed cycle, not to the secretagogue.
The card above states the strength and the count exactly as they ship, and the same 25 mg, 100 tablet pack is what arrives. Orders are packed discreetly, both pricing options are visible on the product page before checkout, and the material is supplied for research reference rather than as a licensed medicine. If ibutamoren is not what you need, the wider Dragon Pharma range covers growth hormone peptides, SARMs and recovery compounds, and our team will answer questions about what a listing contains before you buy.
